Jobs in Cambridge, MA

About the role

The Data, A.I. and Genome Sciences Department is seeking a highly motivated Associate Principal Scientist to join our Genome Science research team in Cambridge, MA. In this experimental biology role, you will develop 3D translational stem cell models in collaboration with the Discovery Immunology Therapeutic Area. This position offers the opportunity to work at the intersection of translational immunology, stem cell biology, and advanced biomarker science. As a member of this team, you will collaborate with cross-functional teams of experimental biologists, data scientists, automation engineers, computational scientists, and Discovery Immunology stakeholders to advance biomarker discovery, translational science, and target validation. The successful candidate will contribute to the development of innovative human translational models and data-driven biological insights that support discovery-stage programs. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

What you'll bring

• PhD in Immunology, Biology, Molecular Biology, Cell Biology, Biological Engineering, Biotechnology, or related STEM field with 4+ years of experience industry and/or applied academic experience.
• Strong background in stem cell biology, 3D translational model development, and human biospecimen-based research.
• Hands-on experience isolating primary cells from human biospecimens, stem cell culture, differentiation, and assay development using primary cells or stem cell-derived model systems.
• Demonstrated experience with iPSC culture, maintenance, gene editing, and/or differentiation.
• Experience developing human 3D models, organoids, and/or co-culture systems.
• Proven ability to design, execute, and interpret complex studies that connect mechanistic biology to clinical hypotheses.
• Strong analytical, problem-solving, and scientific communication skills.
• Ability to lead scientific projects and collaborate effectively with cross-functional teams.
• Proven research accomplishments with a strong publication record.
• Excellent oral and written communication skills, with the ability to present scientific data and project updates to different audiences, including senior leadership.
• 3D Cultures, Assay Development, Autoimmune Diseases, Biochemical Assays, Biochemistry, Cell Biology, Fibrosis, Immunology, Induced Pluripotent Stem Cell (IPSC), Inflammatory Diseases, Mammalian Cell Culture, Omics, Organoid Culture, Stem Cell Culture, Translational Medicine
• Experience with bulk and/or single-cell transcriptomics using primary cells or stem cell-derived model systems, including experimental design and data interpretation.

Benefits