Jobs with visa sponsorship in United States

About the role

We are seeking a talented Senior Scientist to drive our high throughput biology efforts and help us find the next generation of small molecule therapeutics in aging. We’re seeking a driven and highly skilled Senior Scientist to build and execute on our high throughput biology capabilities. In this role, you will be the in-house expert on high throughput assay development and execution — designing and running biochemical and cell-based assays in 384-well format, designing and deploying liquid handling automation and robotics, and turning large compound screening datasets into clear, actionable scientific insights. You’ll partner closely with the rest of our biology team along with medicinal chemistry to enable every stage of small molecule discovery from primary screening through hit-to-lead and lead optimization and you’ll play a central role in shaping how we run our screening platform as the company scales. If you’re someone who loves the challenge of making an assay work at scale and is energized by generating and analyzing large high-quality data sets, we want to hear from you.

What you'll bring

• PhD in biology, biochemistry, chemical biology, or a closely related field.
• 3–5 years of industry experience in a drug discovery setting, with a primary focus on high throughput biology, assay development, or screening sciences.
• Demonstrated expertise in developing and running biochemical and cell-based assays in 384-well plate format for HTS and hit-to-lead.
• Proficiency in Python for data analysis and visualization, including experience building scripts or pipelines to process large, complex screening datasets.
• Strong understanding of assay quality metrics (Z’ factor, S/B, CV) and compound interference mechanisms.
• Excellent scientific communication and cross-functional collaboration skills
• comfortable presenting screening results and data-driven recommendations to a mixed scientific audience.
• Comfort operating independently in a fast-paced startup environment, with the ability to prioritize and manage multiple screening campaigns simultaneously.
• Experience with assay technologies highly relevant to aging or age-related disease biology, including senescence assays, mitochondrial function, proteostasis, or longevity pathway readouts.
• Experience with phenotypic or image-based screening, high content imaging (HCI), and associated image analysis workflows.
• Familiarity with cheminformatics tools and data integration with medicinal chemistry platforms.
• Comfort with cutting-edge data analysis approaches, large datasets, and a curiosity about how AI and machine learning can augment screening science.