Principal Scientist I, Biologics Analytical Research and Development
South San Francisco, CAAll locationsSouth San Francisco, CASan Francisco, CA, United States On-site
$124,500–$236,500 a yearJobFig found this opening at its original source and checks that it remains available.
About the role
We are seeking a highly skilled and motivated analytical scientist to join the Biologics CMC Analytical Research and Development team. This role provides scientific leadership in the development of advanced analytical methods to support biotherapeutic protein characterization, process understanding, and product development. The successful candidate will independently develop innovative approaches and apply state-of-the-art capillary electrophoresis and chromatographic methods, serve as an analytical lead on development teams, and contribute to regulatory strategy and scientific innovation. This position also includes supervisory responsibilities, including leading and mentoring one or more scientists and supporting their performance and development. The role operates within a cross-functional, on-site environment supporting a portfolio that includes multi-specifics, antibodies, ADCs, and novel modalities.
What you'll bring
- Degree in Chemistry, Biochemistry, Analytical Chemistry, or a related field.
- PhD with 6+ years, MS with 12+ years, or BS with 14+ years of relevant industry experience.
- Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
- Demonstrated expertise in analytical method development for biologics, with strong hands-on experience in capillary electrophoresis and HPLC.
- Experience supporting biologics CMC development, QC method qualification/validation, and method transfer.
- Proven ability to interpret complex data, solve technical problems, and propose innovative scientific solutions.
- Experience contributing to regulatory submissions, including quality and characterization sections, and responding to health authority questions.
- Strong leadership, communication, and collaboration skills, with experience mentoring and supervising scientists.
- Must be capable of working in a fast-paced, collaborative environment and managing multiple concurrent projects with a high degree of independence.
- Track record of scientific publications and conference presentations preferred.
- Deep understanding of biologics analytics, impurity profiling, and protein characterization.
- Ability to work effectively across functions and influence scientific and technical decisions.