Bioconjugation Scientist / Chemical Biologist
Cambridge, Massachusetts, United States On-site
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About the role
GT Biosciences is seeking a mission-driven, multidisciplinary Scientist in Organic Chemistry and Bioconjugation to join our Deliveromics Platform Development team. In this role, you will lead the design, synthesis, and characterization of novel ligands, linkers, and conjugates for targeted delivery applications. You will develop and optimize multi-step synthetic routes and bioconjugation strategies across a broad range of molecular formats, including oligonucleotides, peptides, proteins, lipids, small molecules, and other therapeutic payloads. You will work end-to-end, from molecular design and synthesis through purification, analytical characterization, formulation integration, and evaluation in cellular, mouse, and non-human primate studies. You will independently plan and execute experiments, troubleshoot complex chemistry challenges, analyze data, and clearly communicate results. As one of the earliest scientific hires at an emerging biotech, you will help shape our chemistry capabilities, collaborate closely with biologists, formulation scientists, and engineers, and contribute directly to the development of transformative delivery technologies. This is a full-time, in-person position based in Cambridge, MA. What success looks like: You establish a reliable chemistry engine that rapidly turns targeting concepts into purified, fully characterized conjugates ready for formulation and in vivo testing.
What you'll bring
- PhD in organic chemistry, medicinal chemistry, chemical biology, polymer chemistry, pharmaceutical sciences, or a related field
- or an MS/BS with substantial directly relevant industry experience.
- Strong hands-on experience in multi-step organic synthesis, reaction development, route optimization, purification, and structural characterization.
- Demonstrated expertise in bioconjugation or linker chemistry, including selection of reactive handles and chemoselective coupling strategies.
- Experience with analytical and preparative methods such as LC-MS, HPLC/UPLC, NMR, and chromatography used to establish identity, purity, and stability.
- Ability to work with both small molecules and biomolecules, including aqueous or mixed-solvent conditions and sensitive functional groups.
- Excellent experimental judgment, troubleshooting ability, attention to detail, documentation, and scientific communication.
- Resourceful, collaborative, and comfortable taking ownership in a small company with evolving priorities.
- Ability to work onsite five days per week at our Cambridge, MA laboratory.
- Experience conjugating oligonucleotides, peptides, proteins, antibodies, nanobodies, lipids, polymers, or other macromolecular systems.
- Experience with lipid chemistry, ionizable lipids, PEG-lipids, LNP components, or other non-viral delivery systems.
- Familiarity with amine, thiol, maleimide, oxime, hydrazone, strain-promoted click, tetrazine, enzymatic, or cleavable linker approaches.