Principal Engineer, Lentivirus Downstream Process Development
Somerset, New Jersey, United States On-site
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About the role
Legend Biotech is seeking a Principal Engineer, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ. The Principal Engineer, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)—including clarification, chromatography, TFF, sterile filtration and fill/finish—ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.
What you'll bring
- 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
- Strong engineering knowledge of the principles of scaledown model and the interaction of biomolecules, materials and machinery.
- Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors.
- Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
- Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field.
- Ability to implement closed-system processes and maximize cost effectiveness.
- Excellent leadership, emotional intelligence, and communication skills
- ability to maintain composure and strategic focus during challenging development timelines.
- Creative, strategic thinking.
- Strong troubleshooting skills.
- The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting.
- Actual compensation may vary based on experience, skills, qualifications, and geographic location.