Jobs in South San Francisco, CA

About the role

This role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs. We are seeking a highly motivated Senior Scientist II to join the Downstream Development team as a Scale-Up Laboratory Purification Leader. In this role, you will lead laboratory-based scale-up activities to develop, optimize, and transfer robust, phase-appropriate downstream processes for biologic drug substance manufacturing. You will provide technical leadership across scale-up and technology transfer activities while helping advance next-generation purification platform capabilities. This role requires strong technical expertise in downstream development, scale-up and tech transfer, demonstrated leadership skills, and the ability to work effectively in a highly collaborative, team-based, matrixed environment. This position is an onsite laboratory-based role and is best suited for someone who thrives in close partnership with scientists, engineers, and manufacturing teams.

What you'll bring

• Proven ability to troubleshoot equipment issues and work effectively with vendors on repairs, reliability improvements, and technical feedback
• Demonstrated leadership skills with ability to lead projects, influence decisions, and mentor others
• Working knowledge of analytical methods such as HPLC, CE, UV-based quantitation, and impurity characterization used to support downstream development
• Must work effectively in a team-based, highly collaborative, matrixed environment
• Strong written and verbal communication skills, including technical writing and scientific data presentation
• Ability to independently design, execute, and interpret experiments to solve complex technical problems
• Strong understanding of biochemistry and bioprocess engineering principles relevant to downstream development and scale-up
• Strong attention to detail and documentation practices
• Experience leading or overseeing a downstream scale-up laboratory or comparable technical development function
• Hands-on experience supporting transfer of purification processes to pilot-scale, GMP manufacturing, or external CDMOs
• Experience with monoclonal antibodies, bispecifics, or other complex biologic modalities across multiple scales
• Experience advancing platform purification strategies or implementing next-generation technologies to improve robustness, cost, and efficiency

Benefits